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Iron is a fundamental component of hemoglobin synthesis and erythropoiesis, and its delivery at the nanoscale may enhance its uptake and cellular utilization owing to the increased surface area and reactivity 78,79

These disruptions are associated with disease subtypes, progression rates, and clinical outcomes (334, 335, 338354, 358), and studies have shown that iron chelation therapy can delay motor neuron degeneration and extend survival in ALS mouse models (352, 355, 358) ( Figure 8 )

At the time of writing, there are hundreds of trials actively recruiting for participation listed on ClinicalTrials.gov